The 4 Biggest Beauty Breakthroughs of 2017

Smoother skin, fuller lips, and the quickest tattoo-removal ever.

What previously required a scalpel and surgery can now be done in just minutes, which means that results are quicker, more natural-looking, and less painful. 2017 beauty breakthroughs converge on the points of speed and authenticity, making subtle tweaks quicker and more attainable than ever.

The Filler: Volbella XC

Why it wins: It offers a soft, natural look that lasts longer

The newest addition to the lip filler category, Volbella XC is the first and only product FDA approved to erase laugh lines. It is comprised of hyaluronic acid (HA), a molecule that acts as a sponge, absorbing water. HA occurs naturally in the skin, but decreases with age. Volbella XC is unique in that it’s formulated with VYCROSS, a proprietary filler technology which yields a smooth product that blends different molecular weights of HA, which contributes to the gel’s long lasting, softer, more natural results. Over 90 percent of patients reported a natural look and feel at one year post treatment. “A longer lasting lip filler that does not look over the top, is the sweet spot that my patients have been looking for,” says Ellen Marmur, MD, an Associate Clinical Professor in the department of Dermatology and Genetics/Genomic Research at Mount Sinai Medical Center in NYC.

The Laser: PicoSure Tattoo Removal

Why it wins: It clears colors that were previously untreatable.

An ex’s name in green ink? Before Pico, you may have been committed for life. This laser gets rid of stubborn tattoo colors, quicker and more effectively than other available devices. Treatment with Pico actually shatters the tattoo pigment particles so that they can be easily eliminated by the body.

“While more expensive, pico laser systems can essentially reduce the number of treatment sessions needed to eradicate tattoos by half,” notes Tina Alster, MD, Director, Washington Institute of Dermatologic Laser Surgery and Clinical Professor of Dermatology, Georgetown University Hospital. According to Alster, in the U.S., more than 50 percent of people in their 20s have at least one tattoo, and since most tattooed individuals eventually regret getting inked, it makes sense that newer, safer, and faster treatments like Pico are being developed.

The Bodyscultpor: CoolAdvantage Applicator By CoolSculpt

Why it wins: It reduces fat quicker than ever before.

This is not a massive weight loss method. It is more of a kick in the ass to those stubborn areas that just will not budge despite diligent efforts in diet and exercise.

CoolSculpting works by cryolipolysis, the process by which fat cells are literally iced out of your body, and eliminated in urine. Although this is old news, the CoolAdvantage (CAA) applicator came on the scene just this year. CAA delivers safe (and effective) results in 35 minutes, cutting the treatment time by nearly half. It takes me longer to get a blow dry. This device can treat the inner thigh, abdomen, and flanks. Peace out muffin top. Patients may note results as soon as three weeks after treatment, but the fat cells continue to eliminate for up to six months. No surgery or downtime required. “Non-invasive body contouring continues to increase in popularity, and we can really customize treatments now with a multi-modality approach including CoolSculpt for bigger bulges, and Kybella to refine smaller areas of unwanted fat,” says Annie Chiu, MD, attending dermatologist at Cedar Sinai Medical Center in Los Angeles, California.

The Technique: Cannulas

Why it wins: Less bruising and a rejuvenated forehead.

The use of microcannulas (instead of needles) for facial procedures such as filling, has gained popularity this year according to top cosmetic dermatologists. In contrast to needles, cannulas are flexible (think a bendable rubber tube), which in theory, allows for more success when attempting to fill the various contours of facial anatomy, minimizes bleeding and bruising, affords less discomfort, and a decreased risk of bad side effects such as injection of product into a vessel. The idea is that cannulas glide along the tissues causing little damage. Not to mention they provide a fab alternative for the needle-phobic. “I have been using the cannula technique when filling the forehead,” explains Doris Day, MD, Clinical Associate Professor of Dermatology at NYU Langone Medical Center. “I can go through different planes of skin from superficial to deep, and often do this instead of neuromodulator (Botox, Dysport, Xeomin).”

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8 Tips for Sensitive Skin

Follow this advice for happy, calm skin.

Does your skin rebel whenever you try a new product or scrub too hard? Learn how to pamper your skin and avoid common irritants and you’ll have a healthy glow in no time.

1. Test First, Apply Second
When using a new product, always, always do a test run on a small, inconspicuous patch of skin (like behind your ear) before applying. Wait at least 24 hours for signs of irritation, redness, or other skin freak-outs. If your skin is hypersensitive, repeat this test run on a patch next to your eye. All clear? You’re safe to apply with abandon.

2. Don’t Buy “Hypoallergenic” Hype
Hypoallergenic products and sensitive skin are besties, right? Not necessarily. Since there are no federal standards to govern the word “hypoallergenic,” products bearing this claim are not always suitable for sensitive skin. Don’t buy the hype blindly. Refer to tip number 1 before slathering away.

3. Moisturize with Vigilance
Sensitive skin is even more vulnerable to the elements and will benefit from a proper skin-care schedule. Dutifully moisturize both morning and night to protect skin from water loss and to maintain a healthy barrier from the daily onslaught of environmental factors, including pollution and wind.

4. Always Read Labels
Knowledge is power—arm yourself by reading labels. Look for products free from fragrances and paraben preservatives, two common causes of irritation and flare-ups. And the shorter the ingredient list, the better: The American Academy of Dermatology recommends using products with less than 10 ingredients for sensitive skin. The more complicated a formula, the more likely you are to introduce an irritant.

5. Wash Wisely
Keep pores clear and surface debris scarce by washing twice a day (any more can be too much for sensitive skin). Choose a cleanser that is formulated for sensitive skin but isn’t so gentle that you need to scrub really hard to remove makeup or residual grime. Be gentle: blot dry (no rubbing, please) and apply moisturizer straight away for maximum absorption.

6. Go With Less
Sensitive skin is easily overwhelmed so it’s best to keep your everyday skincare products simple: All you really need is a gentle cleanser, moisturizer, and sunscreen.

7. Choose Cosmetics Carefully
Just because your skin is delicate doesn’t mean you have to go sans makeup. Follow these four tips: 1) Use a mineral powder—most of which are free from preservatives and artificial dyes—or a silicone-based foundation to lessen the likelihood of irritation, 2) avoid waterproof mascara as harsh cleansers are required to remove it, 3) use eyeliner in pencil form, not liquid, as the latter often contains latex and may cause a reaction, and 4) toss old cosmetics, which can go bad or become contaminated over time. And don’t forget to clean your brushes regularly.

8. Exercise SPF Smarts
Irritable skin is often extra-sensitive to the sun. Wear sunscreen year-round with SPF 30 or higher to protect delicate tissue from aggravating rays. Look for sunscreens with physical active ingredients—such as zinc oxide and titanium dioxide—which are less likely to cause a reaction than chemical sunscreens, like oxybenzone, octylcrylene, and octinoxate.

Instagrammable Beauty: The best accounts to follow

Instagram is total heaven for the beauty junkies among us. We chart the top accounts to follow if you love all things make-up, skincare and haircare.

1. NARS @narsissist

If you’re a NARS fanatic (much like the entire team at GLAMOUR HQ), you MUST follow this genius Instagram account. You’ll be first to hear about new product launches and beauty trends with this one, but, be warned, it may not be an entirely good influence on your bank account…

2. Rose Gallagher @mixedgemsbeauty

Rose is a beauty personal shopper at Selfridges, and therefore hears about all the great new launches first. The blogger, who writes about her beauty experiences on her website, also shares all of the most exciting new makeup news via her Instagram to thousands of followers. If you’re a beauty junkie, this one’s for you.

3. Vivianna Does Makeup @viviannamakeup

Anna is one of our favourite beauty bloggers, and her Instagram page is filled with birds-eye view make-up layouts, as well as outfit posts and selfies. A necessity for beauty lovers.

4. Cult Beauty @cultbeauty

Cult Beauty is a website that offers shoppers the absolute best in beauty, as its name suggests. Its Instagram page will make you lust after the hottest releases and want to follow the coolest seasonal trends.

5. GLAMOUR UK @GlamourUK

Biased? Us? Well, maybe a little. But if you love makeup, our very own Instagram page is the perfect place to have a leisurely scroll and get some beauty inspiration. You’ll also be the first to know about our seasonal beauty boxes, and to watch our exclusive #GLAMOURtries video series.

6. Charlotte Tilbury @ctilburymakeup

Renowned makeup artist Charlotte Tilbury launched her line a couple of years ago and ever since it has become a firm favourite among celebrities, bloggers and beauty editors alike. Charlotte’s Insta-account not only features her products and ways to use them, but also offers a peek into her glam life, supermodel pals et al.

7. Sephora @sephora

Wondering which beauty bits are making it big stateside? Then this is the perfect page to follow. Certain items are often released across the pond before they are in the UK, so it’s always exciting to see what may be available here in coming months.

8. Jen @beautyjunkieLDN

By following blogger Jen, you will be at the forefront of the beauty industry. Attending all of the most exciting beauty launch events and reporting from the frontline, she promises an exciting Instagram experience for all fellow beauty junkies.

9. Space NK @spacenk

Many of the best beauty brands reside within the walls of your local Space NK branch… which is why their Instagram is a truly ace haven for makeup-a-holics.

10. Pat McGrath @PatMcGrathreal

One of the most influential makeup artists in the world, Pat has worked with numerous high-end brands and some of the most exciting makeup lines around. Add her on Instagram to follow her incredible work and get a view into life as a top artist.

11. Bleach London @bleachlondon

If colourful, fun locks are your thing, this account is for you. Bleach posts regularly, including pictures from their salons, their loyal customers and fans and of their products. WARNING: you may want to run out and dye your hair bright purple after scrolling through their feed.

12. Lisa Eldridge @lisaeldridgemakeup

Lisa Eldridge is of course another highly influential and successful makeup artist who is at the forefront of the beauty industry. Her work and favourite products showcased on her Instagram page are sure to delight.

13. Sarah Bland Barbuto @SarahBland

The nail artist to stars such as Beyonce, Sarah Bland is an expert when it comes to cool colours, shimmering glitters and pretty patterns. She’s also one of the nicest, coolest girls we’ve met!

14. SokoGlam @sokoglam

Charlotte Cho, author of The Little Book of Skincare and co-founder of Soko Glam, the destination for Korean beauty, is a highly knowledgable author and skincare expert. The Soko Glam Instagram page is full of exciting new Korean products and aspirational photos.

15. Dominic Skinner @dominic_mua

If you’re obsessed with Mac makeup, and love to hear about the latest products from the brand, along with the latest techniques, you NEED to give this guy a follow.

16. Alessandra Steinherr @AlexSteinherr

Beauty Director at GLAMOUR, Alessandra is the expert in all things beauty, from skincare to hair. Follow Alex for the ultimate insider beauty news and updates.

10 New Anti-Aging Treatments Doctors Swear By in 2017

The article below talks about the latest procedures for skin rejuvenation. To learn about A.G.E. STOP PRODUCTS WHICH CAN BE USED AT HOME TO MAINTAIN YOUR RESULTS, please visit our website:

www.age-stop.com

So you want to look younger? You’re in luck. The new generation of non-surgical youth-boosters—injectables, lasers, and radiofrequency—address small age-related changes over time. Think reducing fine lines as they develop, rather than trying to reverse deep grooves that have been etched for years, so you look like yourself—only younger, says Joshua Zeichner, MD, director of cosmetic and clinical research in the department of dermatology at Mount Sinai Hospital.

They’re also safer, easier, cheaper, and require much less downtime than solutions past. Trouble is, there are so many options out there—seemingly more every week—that it can be tough to know which will give you the most bang for your cosmetic buck. See which top treatments MDs say are worth booking an appointment for now.

Goal: Lift and define your cheekbones and do away with the “parentheses” lines running from your nose to the corners of your mouth
Old option: Going under the knife for an invasive eye lift, face lift, or silicone cheek implants, which can slide out of position
Fresh approach: Juvederm Voluma XC, a dermal filler
Injecting Voluma into the cheekbone area lifts the skin over your cheekbones, which naturally lessens the visibility of nasio-labial folds, and pulls the skin of the lower eye taut, too, to smooth crows feet, says Neal Schultz, MD, a dermatologist based in New York City. And because of the way the gel is made—with fibers arranged in a cross-hatch pattern, as if forming a dense net, it does a better job of padding sunken spots and lasts longer than other fillers: Up to a year or more vs. the six-month duration other fillers offer, adds Schultz. And unlike implants, Voluma will never slip out of place, because the gel incorporates itself into the skin’s layers. “With Voluma, you get a comparable improvement to surgery—without the risks or the costs,” Schultz says.
Good to know: You’ll see the final result before you leave the office, and there’s no downtime. The most common side effects include minor irritation, swelling or redness at the injection site. (Learn how to balance your hormones naturally—and lose weight for life—with the Hormone Reset Diet.)
Sessions: 1; about $1,200

Goal: Plump lips and fill fine vertical lip lines caused by smoking or sucking on a straw
Old option: Injecting lips with lumpy-looking silicone, which may have to be surgically removed later, or newer, heavier fillers that easily over-fill the lips
Fresh approach: Restylane Silk, a dermal filler

You’ve no doubt seen photos of celebs with over-plumped, strangely lumpy pouts; that’s unlikely to happen with this clear gel, which is made of hyaluronic acid, a hydrating substance that occurs naturally in the body, says Rachel Nazarian, MD, a dermatologist with the Schweiger Dermatology Group in New York City. “Because Restylane Silk isn’t thick, it looks natural when placed into fine lines around the lips, an area that’s notorious for getting overfilled,” she adds. Additionally, the filler gets reabsorbed into the skin after about six months, so if you don’t love the look, it will soften on its own.
Good to know: You’ll get immediate results that last around six months, with zero downtime. The filler contains an anesthetic so there’s no need for pre-numbing, and the most common side effect is temporary swelling.
Sessions: 1 or more as needed; about $800 each

Goal: Tone down fine lines at the corners of your eyes and mouth
Old option: Botox, which can stiffen the area, making it harder for you to make normal facial expressions, or heavy fillers that look unnatural
Fresh approach: Belotero Balance, a dermal filler
“Belotero is super thin, allowing me to get closer to the surface to fill in fine lines precisely,” says dermatologist Dennis Gross, MD, a New York City-based dermatologic surgeon and founder of Dr. Dennis Gross Skincare. Two reasons it’s a home run: Unlike Botox injections around the mouth, you’re at no risk of an eerily expressionless face, Gross adds. And the smooth, hyaluronic acid-based gel integrates fully into your own skin tissue, so you’ll never look like you’ve had “work” done.
Good to know: You’ll see immediate line-lessening results that last around six months. There’s no downtime and only a small chance of side effects (swelling, bruising, redness, pain, or itching). Plus, a major bonus: fillers made from hyaluronic acid have been shown to spur your skin’s natural wrinkle defense by ramping up collagen production and even preventing existing collagen from breaking down.
Sessions: 1; about $800-$900

Goal: Even skin tone and texture by tackling fine lines, acne scars, and age spots
Old option: Microdermabrasion, a facial in which a spray of tiny crystals physically scrapes off the top layer of skin—out-of-sun recovery is a must
Fresh approach: DermaPen, the only FDA approved micro-needling pen

“DermaPen has a cluster of superfine needles that punch microscopic holes in your skin, triggering a healing response that stimulates collagen and elastin production, and ultimately improves the texture and elasticity of your skin,” says New York City-based plastic surgeon Matthew Schulman, MD. Micro-needling has an edge over microdermabrasion because it encourages new collagen to form. Translation: your skin isn’t just smoother, with smaller pores and fewer brown spots, but it’ll end up firmer, too.
Good to know: The downtime ranges from a few hours to 2 to 3 days depending on how deep your treatment goes—it’s customized to your skin’s needs. Results are cumulative, so your skin gets better each time. Side effects include redness and, with more intense treatments, minor scabbing.
Sessions: 5-6; about $500 each

Goal: Treat active acne and erase past acne scars
Old option: Fraxel and C02 lasers, which can cause swelling, redness, oozing, and peeling that can last more than a week.
Next-Gen:  Regenlite Transform Laser
MD says: One treatment with Regenlite, a laser light held close to the skin, can reduce pimples by 50%, says LA-based plastic surgeon Chia Chi Kao, MD. Like other lasers, it uses light to kill acne-causing bacteria and stimulate collagen growth. The key difference: Regenlite doesn’t use heat, which makes the body race to form scar tissue, leading to skin that looks waxy, shiny, stiff, or fibrous. “If you walk around LA, you’ll see people with this pasty, leathery look from more aggressive laser treatments,” Kao says. “Since Regenlite doesn’t heat the skin, it coaxes cells to make collagen that’s soft and pliable, rather than activating your skin’s emergency inflammatory process and scarring.”
Good to know: No anesthesia is required, and there’s little to no downtime. You’ll see some improvement within days but it can take up to 3 months to see full results, which typically last 9 months.
Sessions: 3-5; about $900 each

Goal: Melt stubborn fat pockets
Old option: Liposuction, which is invasive, causes major pain and bruising and puts you out of commission for two weeks, on average
Fresh approach: UltraShape System, body shaping treatment
“It’s the first and only non-invasive body shaping treatment that uses ultrasound energy to target fat without harming the surrounding skin, nerves, and muscles,” says Dennis Gross, MD. UltraShape works by literally shaking fat cells to death—they break apart and disintegrate before heading to the liver for disposal. Just like liposuction, UltraShape trims stubborn fat on the stomach, thighs, butt, and backs of arms, but since it doesn’t require an incision, there’s no risk of infection and you can be back at work the same day. Ultrashape also edges body shaping lasers, which don’t work on all skin tones, Gross says.
Good to know: There’s no anesthesia, no downtime, and no side effects. Expect visible results—an estimated 2 to 3-inch reduction in circumference—two weeks after your first treatment.
Sessions: 3; about $1,400 each

Goal: Repair sun damage by fading sun spots, smoothing wrinkles, and firming loose skin
Old option: Fraxel or C02 lasers, which can cause swelling, redness, oozing, and peeling for 4 to 10 days…or more
Fresh approach: eMatrix, fractional resurfacing using radiofrequency energy
“I’m using eMatrix to treat sun damage—it makes skin smoother, brighter and tighter,” says Jamé Heskett, MD, founder of The Wellpath in New York City. EMatrix delivers radiofrequency (electrical) energy in a grid-like pattern below the skin’s surface, creating tiny skin injuries that prompt collagen to regenerate. “It’s better than Fraxel or C02 lasers because it works below the skin instead of on the surface, so there’s less pain and less downtime with better results,” Heskett says. “It’s the closest thing to a facelift without surgery and downtime,” she says.
Good to know: You’ll see an improvement after the first session but the full treatment requires five. Effects can last 8 to 10 years, but Heskett recommends a single refresher session once a year for maintenance. Side effects include sunburn-like redness for 2 to 3 days after the treatment.
Sessions: 5; $500 each

Goal: Slim and tighten loose skin on your arms
Old option: Titan, Ulthera, which are painful and yield unpredictable results
Fresh approach: Thermi RF, radiofrequency skin tightening device

Thermi RF uses radio waves to melt fat tissue, which eventually drains from the body when you pee. The heat also stimulates collagen, so your skin contracts and tightens after the fat dissolves. This latest radiofrequency technology tightens loose skin and gets rid of bulges, but unlike pervious models, you can count on it yielding results in most patients, not just a few, says Yael Halaas, MD, board-certified facial plastic surgeon in NYC. Thermi RF can be done invasively, with slim cannulas going under the skin to cook fat cells directly. The treatment can also be done using a device that goes on top of your skin, called ThermiSmooth, but it takes multiple monthly sessions.
Good to know: There’s no downtime and you’ll see some difference immediately; your skin will continue to shrink for 3 to 6 months. The main side effect is localized swelling.
Sessions: 1 for Thermi RF (the invasive treatment), $4,000; 3 for ThermiSmooth (the topical treatment), $350 per session

Goal: Tighten loose skin at the neck and beneath the jawline
Old option: Thermage, which doesn’t work in an estimated one in three patients
Fresh approach: Exilis Elite, radiofrequency body contouring

“This radiofrequency technology is less painful, more effective and more reliable than older ones,” says Neal Schultz, MD, a board-certified dermatologist in New York City. He reports that patients often come to him for Exilis after having Thermage with other doctors and being disappointed with the results. “Exilis works every time to tighten and firm loose skin on the neck and jawline.” The technology works by delivering thermal heat down into the skin’s deep layers, stimulating new collagen production.
Good to know: You’ll see results after two treatments, but Schultz recommends the full three to four, and the look lasts for up to two years. There’s no anesthesia, no downtime, and no side effects.
Sessions: 3-4, about $600-$800 each

Goal: Remove redness, whether it’s from rosacea, broken capillaries, dilated blood vessels, acne, acne scars, port wine stains, or cherry angiomas 
Old School: A combo of fine needle electrocautery (where an electric current passes through a tiny wire to destroy the targeted tissue) and alpha hydroxy acids for broken capillaries, and topical (but slow and less effective) lighteners like hydroquinone, kojic acid, or steroid creams for other pigmentation issues
Next Gen: VBeam Perfecta, pulsed dye laser MD says: “It removes those tiny red vessels and pigment spots that give skin a blotchy appearance,” says Maine-based dermatologic surgeon Vermen M. Verallo-Rowell, MD, founder of VMV Hypoallergenics. The secret sauce: the Vbeam uses intense but gentle bursts of light to selectively destroy problematic blood vessels but not the surrounding tissue. They’re then absorbed into the bloodstream and eventually leave the body as waste.
Good to know: There’s no downtime and side effects are minor—just some redness that subsides within a few hours.
Sessions: 3; about $300-$400 each

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Matrixyl Inside® – 25 Years of of Innovation AWARD

NIGHT MIRACLE CREAM by A.G.E. STOP SWITZERLAND contains Matrixyl Inside® as one of the three ESSENTIAL MIMETIC PEPTIDES proven to effectively combat signs of ageing skin. To learn more about this product please visit our website.

www.age-stop.com

Matrikines: the key to anti-ageing

In 1999, the French Professor Maquart and his team published their first article mentioning “matrikines”. What does this term designate? A matrikine is a small molecule composed of a short sequence of amino-acids, a peptide, derived from the surrounding extracellular matrix and constituting a signal in order to regulate cell activity. Matrikines play an important role in the wound healing process and connective tissue remodeling.

How does it work?

In order to react to their environment or to internal stimuli and regulate their activity, the cells use several clearly defined signalling pathways that will transfer information from the cell surface to the internal effector system, most of the time the genes. Thus, a matrikine peptide can link to a matching cell-surface receptor which is coupled to a transducer to relay information into the cell using various signalling pathways (TGF-β, PI3K for example in the case of collagen-1). So it works like a key and a keyhole. It means that the structure of the matrikine is important. Different matrikines can trigger different messages.

skin matrix macromolecule synthesis

Several peptides stimulating the production of molecules having a primary role in the maintenance of the skin properties have been identified by Sederma Research Laboratories.

What is Matrixyl®?

Matrixyl® is a trade mark of Sederma SAS. It designates an anti-wrinkle active ingredient for cosmetics containing a specific matrikine which cosmetic nomenclature denomination is palmitoyl pentapeptide-4 (palmitoyl pentapeptide-3 before 2006). It contains a peptide of 5 aminoacids linked to a 16-carbon chain for improving the penetration of the molecule through the lipidic structures of the skin.

The history of Matrixyl Inside®

The first member of the Matrixyl Inside® range was Matrixyl® launched by Sederma in 2000. Then, in order to satisfy the increasing anti-ageing market, Sederma launched in 2003 Matrixyl® 3000 based on two peptides: a palmitoyl tripeptide and a palmitoyl tetrapeptide. Finally, in 2012, Sederma launched a different palmitoyl tripeptide under the trade name Matrixyl® synthe’6®. So far, the Matrixyl Inside® range contains three products.

Which one is better?

None! They are all different and perform different efficacy. For example, Sederma has recently demonstrated with ex vivostudies that Matrixyl® 3000 shows great results in repairing photo-aged skin and defragmented collagen network at the level of the dermis. The crow’s feet wrinkles decrease by 33% after applying a cream for two months. Matrixyl® synthe’6®stimulates the synthesis of collagen but also five other major constituents of the skin. The volume of the forehead wrinkles can decrease by 31% until a dramatic smoothing effect in just two months.

All those products underwent extensive research for efficacy and safety, and are patented. Matrixyl®, Matrixyl® synthe’6®and Matrixyl Inside® are trademarks of Sederma SAS.

 

PhytoCellTec™ Nunatak®

PhytoCellTec™ Nunatak® is a cosmetic ingredient based on stem cells of Saponaria pumila, an Alpine plant that survived the last ice age. This amazing ingredient is present in PERFECTION CONCENTRATE from A.G.E. STOP SWITZERLAND Luxury Swiss Anti-Aging Products.

www.age-stop.com

Saponaria pumila
Saponaria pumila is an extremophile plant of alpine mountains that survived the last ice age by moving to rare ice-free peaks called nunataks. Constantly exposed to cold and high amounts of UV, this plant developed protecting and repair mechanisms that enabled it to adapt to its challenging environment.

Plant stem cells for skin stem cells
The development of the innovative PhytoCellTec™ technology made possible to grow plant stem cells on a large scale. It also became possible to effectively cultivate rare and protected plants like the Saponaria pumila and to make them available for cosmetics for the first time.

The effect
Mibelle Biochemistry was able to show in extensive studies the capacity of PhytoCellTec™ nunatak® to maintain the regenerative potential of human dermal stem cells despite UV. This protective effect led to an increase in skin elasticity, firmness and density already after 4 weeks’ treatment.

Summary
Thanks to the PhytoCellTec™ technology, the survival potential of the extremophile Saponaria pumila plant can be transferred to the cells of our skin in order to protect the latter against daily environmental challenges which are the main cause of skin aging.

Protects dermal stem cells against UV stress
Cultures of human dermal stem cells were treated with PhytoCellTec™ nunatak®, while others were left untreated. The cultures were then exposed to UVA and UVB rays. The capacity of the stem cells to grow in colonies and form three-dimensional spheres was then measured. The results showed that UV radiation strongly reduced the number of spheres that were formed. Treatment with PhytoCellTec™ nunatak® was found to protect against irradiation as the sphere number was 35 % higher compared to the unprotected control (figure 1).

Increase of skin density 
The dermal tissue structure of forearms from volunteers with sun-damaged skin was visualized by ultrasonography before and after treatment with PhytoCellTec™ nunatak® (figure 2). In the ultrasonographic images the dermis appears in bright colours, whereas the so-called subepidermal low echogenic band (SLEB) produces dark patches. This SLEB is the result of a disrupted architecture of the dermis and commonly found in aged and photo-damaged skin. Results clearly show, that a 28 days treatment with PhytoCellTec™ nunatak® reduces the SLEB and significantly improves the dermal tissue density.

Increase of skin elasticity and firmness
The effects of PhytoCellTec™ nunatak® on skin elasticity and firmness were demonstrated in a clinical study including 20 volunteers with sun-damaged skin, average age 53.5. A cream with 0.4% PhytoCellTec™ nunatak® was applied to the inner side of their forearms twice daily for 28 days. Results showed a significant increase of both parameters compared to initial conditions. In particular, the increase in firmness was especially high – more than 14 % compared to the placebo after just one month of treatment

PhytoCellTec™ Alp Rose

Both A.G.E. STOP Night Cream and Sleeping Mask contain PhytoCellTec™ Alp Rose (Stem cells from Swiss Alpine Rose) researched, patented and integrated into skincare by Swiss Mibelle Biochemistry. To discover these products – please visit our website

www.age-stop.com

PhytoCellTec™ Alp Rose is a cosmetic ingredient based on stem cells of alpine rose leaves.

The Alpine rose
The alpine rose is a typical Swiss flowering plant from the Alps. It has bright pink blossoms and grows at altitudes up to 3200 m. Its evergreen leaves are especially resistant to high UV radiation and extreme dryness and cold. The sturdy leaves are a shiny green, even once the snow has melted in the spring. This phenomenon is due to the presence of a special protection protein called dehydrin in the leaves of the alpine rose.

Plant stem cells for skin stem cells
For years researchers at Mibelle Biochemistry have investigated the compounds of the alpine rose and its special protective substances, in particular, the water-retaining dehydrin. The innovative PhytoCellTec™ technology has been used to develop a formula from the leaves’ stem cells that treats dry and stressed skin and has been proven to protect skin cells: PhytoCellTec™ Alp Rose.

The effect
Mibelle Biochemistry was able to show in extensive studies that PhytoCellTec™ Alp Rose promotes the vitality and longevity of skin stem cells. It strengthens the skin barrier, providing better protection to the skin against climate-induced stress.

Summary
The effect of PhytoCellTec™ Alp Rose combines two important approaches. Using plant stem cells delays skin aging by protecting vital skin stem cells, keeping the skin looking youthful longer, and giving it a better and more vital appearance. At the same time, PhytoCellTec™ Alp Rose protects the skin using special protective ingredients from this extremely resistant alpine plant.

Protects epidermal stem cells from UV stress
Cultures of epidermal stem cells were treated with PhytoCellTec™ Alp Rose, while others were left untreated. The cultures were then exposed to UVA and UVB rays. The colony-forming efficiency (CFE) of the stem cells was then measured. The results showed that UV radiation strongly reduces the cells’ colony-forming efficiency. Treatment with PhytoCellTec™ Alp Rose increased the stem cells’ colony-forming efficiency (vitality) and provided significant protection against UV rays.

Ski holiday study
Twenty-two subjects were treated with an SPF 30 sunscreen formula during their ski holidays (1 week in March, Alps) to test the effect of PhytoCellTec™ Alp Rose in extreme environmental conditions. Sunscreen without the active ingredient was applied to one side of a subject’s face, while the other side was treated with sunscreen containing the active ingredient PhytoCellTec™ Alp Rose. The loss of skin moisture in the face was then measured after another week of treatment at home. The results showed that water loss was reduced by 39% after 2 weeks’ treatment with PhytoCellTec™ Alp Rose. This indicates that PhytoCellTec™ Alp Rose strengthens the skin barrier and makes it more resistant to environmental stresses such as UV, wind, cold temperatures and dryness.